WebGeneralized Myasthenia Gravis (gMG) SOLIRIS is a prescription medicine used to treat adults with a disease called generalized myasthenia gravis (gMG) who are anti-acetylcholine receptor (AChR) antibody positive. It is not known if … Eculizumab, sold under the brand name Soliris among others, is a medication used to treat paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), generalized myasthenia gravis, and neuromyelitis optica. In people with PNH, it reduces both the destruction of red blood cells and … See more Eculizumab is used to treat atypical hemolytic uremic syndrome (aHUS) and paroxysmal nocturnal hemoglobinuria (PNH). For people with PNH, it improves quality of life and decreases the need for blood transfusions … See more Eculizumab carries a black box warning for the risk of meningococcal infections and can only be prescribed by doctors who have enrolled in and follow a risk evaluation and mitigation strategy See more Legal status Eculizumab was approved by the US Food and Drug Administration (FDA) in March 2007 for the treatment of PNH, Eculizumab has … See more Eculizumab specifically binds to the terminal complement component 5, or C5, which acts at a late stage in the complement cascade. When activated, C5 is involved in … See more • "Eculizumab". Drug Information Portal. U.S. National Library of Medicine. See more
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WebFeb 17, 2024 · Soliris is indicated in adults and children for the treatment of: - Paroxysmal nocturnal haemoglobinuria (PNH). ... the medicinal product should be used immediately. However, chemical and physical stability has been demonstrated for 24 hours at 2°C – 8°C. 6.4 Special precautions for storage. Store in a refrigerator (2°C – 8°C). WebMethods for manufacturing injector devices, including positioning a stopper of the injector device in a tubular member such that an outer side of the stopper is engaged with an inner surface of the tubular member and modifying the outer side of a stopper by causing relative motion between the stopper and the tubular member, the relative motion including one or … WebSoliris is presented as a concentrate for solution for infusion (300 mg/vial) and is diluted in sodium chloride or in a dextrose solution prior to administration. Active Substance • Nomenclature INN Name: eculizumab Compendial Name: not applicable Chemical Name: immunoglobulin, anti (human complement C5 α chain) (human mouse ray rice violence tape