Cdc14 specificity
WebNov 23, 2011 · In contrast, the phosphatase Cdc14, which counteracts CDK during mitotic exit, showed a higher specificity for the T320S-T347S sensor (Fig. 3H and fig. S3G), which is also in agreement with a ... WebSep 29, 2024 · 65 specificity it imparts, is a signature feature of Cdc14 enzymes across eukaryotes. The broad conservation 66 implies Cdc14 specificity must fill an essential niche in cellular regulation of most eukaryotic species that 67 cannot be provided by other prominent protein phosphatases. One hypothesis, based on work in the 68 oomycete
Cdc14 specificity
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WebCDC14A. Dual specificity protein phosphatase CDC14A is an enzyme that in humans is encoded by the CDC14A gene. [5] [6] [7] The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit ... WebCD14: a transmembrane protein found on monocytes, macrophages, neutrophils, some B cells, and dendritic cells that is involved in signal transduction leading to oxidative burst …
WebThe Cdc14 dual-specificity phosphatases regulate key events in the eukaryotic cell cycle. However, little is known about the function of mammalian CDC14B family members. Here, we demonstrate that subcellular localization of CDC14B protein is cell cycle regulated. CDC14B can bind, bundle, and stabilize microtubules in vitro independently of its ... Webdual specificity protein phosphatase CDC14B, CDC14 cell division cycle 14 homolog B. GeneRIFs: Gene References Into Functions. Downregulation of CDC14B in 5218 breast …
WebApr 10, 2014 · Refinement of Cdc14 Specificity and Prediction of Yen1 as a Substrate. Cdc14 enzymes display a strong preference for basic amino acids downstream of pSer-Pro (Bremmer et al., 2012). Phosphopeptides lacking basic residues in the +2 to +6 region relative to pSer-Pro are poor substrates. However, we did not previously explore the …
WebIn this study, we showed that the CDC14 ortholog is important for pathogenesis and morphogenesis in Fusarium graminearum. FgCDC14 is required for normal cell division and septum formation and FgCdc14 possesses phosphatase activity with specificity for a subset of Cdk-type phosphorylation sites.
WebOct 30, 2013 · A dual-specificity, paralogue-free Cdc14 phosphatase was located in the nuclei of Beauveria bassiana (filamentous entomopathogen) and functionally characterized. Inactivation of cdc14 caused ... sla of p1 ticketWebSep 29, 2024 · 65 specificity it imparts, is a signature feature of Cdc14 enzymes across eukaryotes. The broad conservation 66 implies Cdc14 specificity must fill an essential … sla of nyWebThus it is important to define Cdc14 active site substrate specificity and identify residues that are essential for Cdc14 catalysis. Interestingly, the Cdc14 phosphatases contain the active site sequence CX 5 R, which is a hallmark for the protein tyrosine phosphatase (PTP) superfamily. The PTPs are a diverse family of enzymes that includes ... sla of vmWebThe protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and … sla of dapWebMay 24, 2003 · The Cdc14 family of dual-specificity protein phosphatases (DSPs) is conserved within eukaryotes and functions to down-regulate mitotic Cdk activities, promoting cytokinesis and mitotic exit. We have integrated structural and kinetic analyses to define the molecular mechanism of the dephosphorylation reaction catalysed by Cdc14. The … sla of paymentWeband specificity factors that target relevant substrates for proteolysis. In budding yeast, Cdh1 is the relevant target-ing factor for the APC at the exit from mitosis, and Cdh1 ... (CDC14) identified in the original screen by Hartwell and colleagues (Hartwell et al. 1974) for mutants that affected the cell division cycle. There were several mutants sla online surreyWebspecificity for other Cdc14 orthologs, such as Cdc14 in S. cerevisiae (ScCdc14), Cdc14 in F. graminearum (FgCdc14), and Cdc14 in M. oryzae (MoCdc14), suggesting that inhibitors that are efficient on AnCdc14 could also inhibit its orthologs and vice versa. An initial screening of 10,000 potential Cdc14 inhibitors at the Bindley Bioscience sla performance fortigate