Breast cancer klf5

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August undefined, 2024

WebJul 12, 2024 · Breast cancer is the most common disease and the leading cause of cancer-associated mortality in women worldwide . At present, several strategies are employed for the treatment of early breast cancer, ... KLF5, a downstream protein of YAP, had the lowest expression in the UM+SIM group (Fig. 4A). WebExpression of KLF5 (BTEB2, CKLF, IKLF) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.

Targeting the KLF5-EphA2 axis can restrain cancer

WebFigure 8.1. Relationships between steroid hormones and KLF5 in breast cells. ① Estrogen and ERα induce the expression of the EFP E3 ubiquitin ligase, which targets KLF5 for degradation in ERα-positive breast cancer cells. ② KLF5 interacts with ERα to suppress ERα-mediated transcription of c-Myc and CSTD in ERα-positive breast cancer cells. ③ … WebIn breast cancer, KLF5 promotes cancer cell proliferation and the cell cycle by inducing transcription of FGF-BP1, 25 mPGES1, 26 TNFAIP2, 27 and Cyclin D1 4 and inhibiting transcription of p27 5 and p21. 26 KLF5 maintains cell stemness by inducing the transcription of Slug 7 and Nanog. 6 KLF5 is essential for progesterone to induce cell ... ether melting and boiling point

Breast cancer metastasis suppressor 1 gene - National Library of ...

WebApr 24, 2024 · Triple negative breast cancer (TNBC) is one of the most aggressive breast cancers without effective targeted therapies. Numerous studies have implied that KLF5 plays an important roles in TNBC. How is KLF5 regulated by microRNAs has not been well studied. Here, we demonstrated that miR-217 down-regulates the expression of KLF5 … WebThe long noncoding RNA (lncRNA) LINC00152, also known as CYTOR, displays aberrant expression in various cancers. However, its clinical value and functional mechanisms in breast cancer remain insufficiently understood. Our study found that LINC00152 is significantly upregulated in breast cancer, and that it acts as an indicator of poor … WebMar 19, 2024 · Breast cancer, cervical cancer, hepatocellular carcinoma, and bladder cancer are all aided by KLF5 [29–31]. Furthermore, KLF5 expression has been linked to a poor prognosis in lung cancer, and in vitro tests have shown that a decrease of KLF5 may overcome cisplatin resistance in lung cancer [ 32 ]. ether metabolism

Tyrosine kinase SRC-induced YAP1-KLF5 module regulates cancer …

Targeting the KLF5-EphA2 axis can restrain cancer ... - ResearchGate

WebJun 1, 2010 · The KLF5 transcription factor has been shown to play important roles in cancer ().Accumulated evidence suggests that KLF5 promotes fibroblast, colon, bladder, … WebDec 10, 2013 · KLF5 function is aberrantly affected at the protein level in breast cancer, through excessive protein degradation or enhanced cytoplasmic localization 58, 63. Loss of the 13q21-q22 genomic region, … e therm gmbhWebApr 24, 2024 · KLF5 depletion leads to breast cancer cell apoptosis and suppresses xenograft tumor growth in vivo [13, 14]. Importantly, pharmacological inhibition of KLF5 by mifepristone leads to suppression of TNBC stem cells . In conclusion, KLF5 is a potential therapeutic target for TNBC. ethermine alternative

"WebSep 30, 2015 · The transcription factor KLF5 is highly expressed in basal-like breast cancer and promotes breast cancer cell proliferation, survival, migration and tumour growth. … " - Breast cancer klf5

Breast cancer klf5

Metastatic progression and gene expression between breast cancer …

WebHere, based on clinical database, we demonstrate a positive correlation between Kruppel-like factor 5 (KLF5) and YB-1 expression in breast cancer patients, but a negative correlation with that of Dachshund homolog 1 (DACH1). Mechanistically, YB-1 enhances KLF5 expression not only through transcriptional activation that can be inhibited by … WebJan 24, 2024 · Background Metastasis causes the majority of cancer-related deaths worldwide. Increasing studies have revealed that circRNAs are associated with the carcinogenesis and metastasis of many cancers. Nevertheless, the biological mechanisms of circRNAs in breast cancer (BC) liver metastasis remain extremely ambiguous. …

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WebApr 8, 2024 · Breast cancer is the second lethal cancer in women, with the highest number of new cases . The effect of KLF4 on breast cancer is “controversial”. ... but not KLF5, in bladder cancer. Biochem ... WebLi-Fraumeni syndrome [ 82 ] Inherited mutation in TP53 gene.Affected family members at increased risk of bone tumors, breast cancer, leukemia, brain tumors, and sarcomas.17p13. 1 P53 DNA damage response Paget disease [ 83 ] Excessive ...

WebOct 11, 2024 · In conclusion, these findings suggested that the KLF5/miR-125b-5p/BRCA1 axis may provide new information on radiation therapy for breast cancer. A large number of clinical trials have proved that radiotherapy is an effective strategy for treating breast cancer (BC), but radioresistance is an urgent WebOct 17, 2024 · The Krüppel-like factor 5 (KLF5) transcription factor is highly expressed in basal type breast cancer and promotes breast cancer cell proliferation, survival, migration, and tumorigenesis.

WebNov 11, 2024 · We conclude that USP3 confers drug resistance in breast cancer cells independently of KLF5. Discussion. KLF5 has been implicated as an oncogene and therapeutic target in a number of cancers including breast, colon, bladder, lung, stomach, and ovarian cancer . Therefore, it is important to thoroughly understand the upstream … WebMay 28, 2024 · In breast cancer, KLF5 plays oncogenic roles by regulating a wide range of downstream genes. For example, KLF5 induces the transcription of Cyclin D1, FGF-BP1, mPGES1, TNFAIP2 and Slug, while it suppresses the transcription of p27 and p21 to promote cell proliferation [20, 21]. However, previous studies on KLF5 have mainly …

WebSep 3, 2024 · KLF5 has been shown to have a tumour promoting function in pancreatic (He et al., 2024) and basal-like breast cancer (Qin et al., 2015). KLF5 is also frequently amplified in gastric cancer (Chia et al., 2015; Zhang et al., 2024) and has recently been shown to regulate gene expression in OAC in combination with other transcription …

WebNov 22, 2024 · USP3 stabilizes KLF5. A, KLF5 and USP3 protein expression levels in immortalized mammary epithelial cell lines (MCF10A and 184B5) and nine breast … ethermine calculatorWebApr 21, 2016 · The Kruppel-like factor 5 (KLF5) transcription factor is highly expressed in high-grade and basal-like breast cancers. However, the mechanism by which KLF5 … ether metabolizeWebMay 16, 2009 · KLF5 has potential as a biomarker for diagnosis and prognosis in cancers and cardiovascular diseases. The expression of KLF5 mRNA associates with reduced survival in patients with breast cancer . … ethermine asia serverWebJan 13, 2024 · A Western blotting showed the expression of KLF5, YB-1 and DACH1 in immortalized mammary epithelial and breast cancer cell lines.B The analysis of … ethermine access is deniedWebJan 12, 2024 · SRC is the first identified oncogene, and its aberrant activation has been implicated as a driving event in tumor initiation and progression. However, its role in cancer stemness regulation and the underlying regulatory mechanism are still elusive. Here, we identified a YAP1 tyrosine phosphorylation-dependent YAP1-KLF5 oncogenic module, … firehouse all she wrote acousticWebMay 9, 2024 · Introduction. Breast cancer is still the most malignant female tumor in the world. It has been estimated that about 249,260 new cases and 40,890 deaths from … ether methyl etherWebJul 11, 2007 · In a recent study, patients with breast cancer having higher KLF5 expression had both shorter disease-free survival and overall survival and the result of the study showed that KLF5 expression is a prognostic factor for breast cancer (Tong et al. 2006). However, it plays an inhibitory role in cell growth in cancer cells as well. ... firehouse all she wrote guitar lesson